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Spatial RegistrationCIOD
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PatientMModule - Patient
(0008,1120) Referenced Patient Sequence3Sequence
(0010,0010) Patient's Name2Person Name
(0010,0020) Patient ID2Long String
(0010,0021) Issuer of Patient ID3Long String
(0010,0022) Type of Patient ID3Code String
(0010,0024) Issuer of Patient ID Qualifiers Sequence3Sequence
(0010,0026) Source Patient Group Identification Sequence3Sequence
(0010,0027) Group of Patients Identification Sequence3Sequence
(0010,0030) Patient's Birth Date2Date
(0010,0032) Patient's Birth Time3Time
(0010,0033) Patient's Birth Date in Alternative Calendar3Long String
(0010,0034) Patient's Death Date in Alternative Calendar3Long String
(0010,0035) Patient's Alternative Calendar1CCode String
(0010,0040) Patient's Sex2Code String
(0010,0200) Quality Control Subject3Code String
(0010,0212) Strain Description3Unlimited Characters
(0010,0213) Strain Nomenclature3Long String
(0010,0216) Strain Stock Sequence3Sequence
(0010,0218) Strain Additional Information3Unlimited Text
(0010,0219) Strain Code Sequence3Sequence
(0010,0221) Genetic Modifications Sequence3Sequence
(0010,0222) Genetic Modifications Description1Unlimited Characters
(0010,0223) Genetic Modifications Nomenclature1Long String
(0010,0229) Genetic Modifications Code Sequence3Sequence
(0010,1001) Other Patient Names3Person Name
(0010,1002) Other Patient IDs Sequence3Sequence
(0010,1100) Referenced Patient Photo Sequence3Sequence
(0010,2160) Ethnic Group3Short String
(0010,2201) Patient Species Description1CLong String
(0010,2202) Patient Species Code Sequence1CSequence
(0010,2292) Patient Breed Description2CLong String
(0010,2293) Patient Breed Code Sequence2CSequence
(0010,2294) Breed Registration Sequence2CSequence
(0010,2297) Responsible Person2CPerson Name
(0010,2298) Responsible Person Role1CCode String
(0010,2299) Responsible Organization2CLong String
(0010,4000) Patient Comments3Long Text
(0012,0062) Patient Identity Removed3Code String
(0012,0063) De-identification Method1CLong String
(0012,0064) De-identification Method Code Sequence1CSequence
Clinical Trial SubjectUModule - Patient
General StudyMModule - Study
Patient StudyUModule - Study
Clinical Trial StudyUModule - Study
General SeriesMModule - Series
Clinical Trial SeriesUModule - Series
Spatial Fiducials SeriesMModule - Series
General EquipmentMModule - Equipment
Spatial FiducialsMModule - Spatial Fiducials
Common Instance ReferenceMModule - Spatial Fiducials
General ReferenceUModule - Spatial Fiducials
SOP CommonMModule - Spatial Fiducials
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Generic Implant TemplateCIOD
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CT Performed Procedure ProtocolCIOD
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Protocol ApprovalCIOD
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Ophthalmic Optical Coherence Tomography En Face ImageCIOD
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Basic DirectoryCIOD

Built with by Innolitics, a team of medical imaging software developers.

Data synced with official DICOM standard on 18 April 2024. The DICOM Standard is under continuous maintenance, and the current official version is available at http://www.dicomstandard.org/current/. DICOM Parts 3, 4, and 6, © NEMA. Please note that the most recent PDF version of the standard is the official reference, and should checked when making technical decisions.

Genetic Modifications Sequence Attribute

Tag(0010,0221)
TypeOptional (3)
KeywordGeneticModificationsSequence
Value Multiplicity1
Value RepresentationSequence (SQ)

The genetic modifications of the Patient.

One or more Items are permitted in this Sequence.

See Section C.7.1.1.1.4.

Section C.7.1.1.1.4

C.7.1.1.1.4 Patient Strain and Genetic Modifications

The strain of a non-human organism (group of non-human organisms that is genetically uniform), if known, may be encoded in Strain Description (0010,0212). The nomenclature used may be encoded in Strain Nomenclature (0010,0213). A precoordinated code identifying the strain may be encoded in Strain Code Sequence (0010,0219).

Defined Terms for Strain Nomenclature (0010,0213) and Genetic Modifications Nomenclature (0010,0223):

MGI_2013

International Committee on Standardized Genetic Nomenclature for Mice, Rat Genome and Nomenclature Committee. MGI-Guidelines for Nomenclature of Mouse and Rat Strains. 2013/10. Available from: http://www.informatics.jax.org/mgihome/nomen/strains.shtml

Note

  • A pair of text and nomenclature Attributes are used, since standard nomenclatures typically define values that are constructed from multiple components, and do not distinguish between value and meaning. These are distinct from the precoordinated codes used in Strain Code Sequence (0010,0219).

  • Some strain and genetic modification nomenclatures make use of superscripts. To encode these superscripts consistently in an unformatted string, the convention of enclosing the superscript text in "<" and ">" pairs may be used. E.g., "D2.B6-Ahrb-1/J" would be encoded as "D2.B6-Ahr<b-1>/J".

  • Relevant information that is not encoded in the formal description of the strain (i.e., not defined in the nomenclature used), such as the number of transgenes, may be encoded as plain text in Strain Additional Information (0010,0218).

The strain of a non-human organism may be more specifically identified by the Attributes within Strain Stock Sequence (0010,0216).

Note

  • The MGI-Guidelines for Nomenclature of Mouse and Rat Strains recommends the use of the laboratory codes assigned by the Institute of Laboratory Animal Research (ILAR). See the International Laboratory Code Registry (ILCR) http://dels.nas.edu/global/ilar/lab-codes.

  • Because allele names are closely tied to gene names/symbols it is necessary to have a unique and permanent code for any allele that is part of a genotype of interest. For mice, MGI is the authoritative source of the nomenclature for genes and alleles and maintains unique, permanent codes for these entities. The MGI provides a report of all precoordinated MGI codes that are assigned to specific strains at http://www.informatics.jax.org/downloads/reports/MGI_Strain.rpt. These may be used in Strain Code Sequence (0010,0219) and Genetic Modifications Code Sequence (0010,0229) with a coding scheme of "MGI".

  • Another source of pre-coordinated codes for strains is the NCI Thesaurus, which includes a snapshot of strains from the International Mouse Strain Resource (IMSR), as children of (C14421, NCIt, "Inbred Mouse Strains"). See http://ncit.nci.nih.gov/ncitbrowser/pages/concept_details.jsf?dictionary=NCI_Thesaurus&code=C14421.

  • For example, a C57BL/6J mouse strain from The Jackson Laboratory might be identified as:

    • Strain Description (0010,0212) = "C57BL/6J"

    • Strain Nomenclature (0010,0213) = "MGI_2013"

    • Strain Code Sequence (0010,0219)

      • >Code Value (0008,0100) = "3028467"

      • >Coding Scheme Designator (0008,0102) = "MGI"

      • >Code Meaning (0008,0104) = "C57BL/6J"

    • Strain Stock Sequence (0010,0216)

      • >Strain Stock Number (0010,0214) = "000664"

      • >Strain Source (0010,0217) = "Jrep"

      • >Strain Source Registry Code Sequence (0010,0215)

        • >>Code Value (0008,0100) = 126850

        • >>Coding Scheme Designator (0008,0102) = "DCM"

        • >>Code Meaning (0008,0104) = "ILCR"

  • For example, a FVB/N mouse with a Tg(MMTV-Erbb2*)NDL2-5Mul transgene might be identified as:

    • Strain Description (0010,0212) = "FVB/N-Tg(MMTV-Erbb2*)NDL2-5Mul"

    • Strain Nomenclature (0010,0213) = "MGI_2013"

    • Genetic Modifications Sequence (0010,0221)

      • >Genetic Modifications Description (0010,0222) = "Tg(MMTV-Erbb2*)NDL2-5Mul"

      • >Genetic Modifications Nomenclature (0010,0223) = "MGI_2013"

      • >Genetic Modifications Code Sequence (0010,0229)

        • >>Code Value (0008,0100) = "3793949"

        • >>Coding Scheme Designator (0008,0102) = "MGI"

        • >>Code Meaning (0008,0104) = "Tg(MMTV-Erbb2*)NDL2-5Mul"

    In this example, a precoordinated code for the genetic modification is defined in MGI, but not for the mouse strain.